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Published Jan 11, 23
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Disturbances in the sense of smell, eye and vision issues, sleep problems, depression, anxiety, pain, psychosis, fatigue, cognitive changes, weight loss, lightheadedness, sweating, melanoma, personality changes, and gastrointestinal, urinary, and sexual issues can all occur in patients of Parkinson’s disease. Parkinson's Disease Medications & Treatment There is no cure for Parkinson’s disease.

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Side-effects include nausea, usually requiring it to be taken with carbidopa. If symptoms return between doses (OFF periods) an infison of levodopa that is administered through a tube called duopa, a powder form of levodopa which can be inhaled, or the new medication istradefylline (Nourianz) may be prescribed. Levodopa treatments are often delayed as long as possible as its effects wear off over time and it eventually stops working, causing the patient to develop movement problems called “motor fluctuations”.

Side effects include trouble falling or staying asleep, nausea, falls, and uncontrolled, involuntary movements. that imitate the action of dopamine in the brain to treat the motor symptoms of Parkinson’s disease. Examples include pramipexole, rot ropinirole and igotine that can be taken on their own or with levodopa. Side effects can include nausea, orthostatichypotension, hallucinations, somnolence, and impulse control disorders.

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These include eating a healthy diet and a proper exercise program to help maximize the potential of medications, increase energy, and promote general health and well-being in Parkinson’s patients. Physical, occupational and speech therapies can help with walking and gait issues, fine motor skills, and speech and language issues that may arise with Parkinson’s disease while deep brain stimulation (DBS) may improve symptoms in certain patients.

However, the main body of evidence showing that CBD has promise as an effective treatment for this disease lies in studies relating to adjunct actions and complications from the disease including oxidative stress, neural inflammation and neurodegeneration. One such study is from 2011 in which researchers published the findings of the journal Psychopharmacology.

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Using an animal model of cognitive impairment induced by iron overload, they tested the effects of CBD in memory-impaired rats in both a single dose as well as continued use. In the first experimental condition, the researchers administering a single dose of either 5. 0 mg/kg or 10. 0 mg/kg of CBD immediately after a training session of the novel object recognition task.

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They found that a single dose of 10. 0 mg/kg of CBD recovered memory while repeated CBD administration of either CBD dose improved recognition memory. They concluded that the evidence suggests that CBD shows potential for the treatment of cognitive decline associated with neurodegenerative disorders. Testing the efficacy of CBD for the management and treatment of Parkinson’s disease in a double-blind, clinical trial with patients diagnosed with Parkinson’s disease, they published their findings in the Journal of Psychopharmacology in 2014.

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The control group was treated with a placebo, the first experimental group with 75 mg/day of CBD and the second experimental group with 300 mg/day of CBD. Participants were assessed in respect to motor and general symptoms, well-being and quality of life, and possible neuroprotective effects one week before and again, during the last week of treatment.

However, the researchers also noted that studies with larger samples and specific objectives are required before definitive conclusions can be drawn. In contrast, the latest research from 2020 suggests that CBD can help with motor symptoms, specifically tremors. In the Journal of Psychopharmacology, researchers published the results from their study aimed at evaluating the impact of a single dose of 300 mg CBD on anxiety measures and tremors induced by a Simulated Public Speaking Test (SPST) in individuals with Parkinson’s disease.

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In a 2015 study published in Toxicology in Vitro, scientists investigated the potential neurorestorative effects of CBD and the pathways that mediate it for the treatment of Parkinson’s disease. They used rat neurons treated with a neurotoxin that is known to induce Parkinson's disease in vivo and presents with neuroinflammation, excitotoxicity, mitochondrial dysfunction and reduced neurotrophic support.

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